Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2007 Sep;127(9):2098-100.
doi: 10.1038/sj.jid.5700947.

Defining hair follicles in the age of stem cell bioengineering

Cheng-Ming Chuong  1 , George Cotsarelis, Kurt Stenn
Affiliations
Comment

Defining hair follicles in the age of stem cell bioengineering

Cheng-Ming Chuong et al. J Invest Dermatol. 2007 Sep.

Abstract

One challenge faced by stem cell biologists is the bioengineering of an organ. Ehama et al. (2007, this issue) used cells derived from human and rodent epidermis and dermal papilla to reconstitute hair-follicle mini-organs. Some result in hair follicles; others are hair follicle-like. The challenge calls for the development of a set of criteria to define a hair follicle so that bioengineered products in the future can be evaluated.

PubMed Disclaimer

Conflict of interest statement

CONFLICT OF INTEREST

The authors state no conflict of interest.

Comment on

  • Hair follicle regeneration using grafted rodent and human cells.
    Ehama R, Ishimatsu-Tsuji Y, Iriyama S, Ideta R, Soma T, Yano K, Kawasaki C, Suzuki S, Shirakata Y, Hashimoto K, Kishimoto J. Ehama R, et al. J Invest Dermatol. 2007 Sep;127(9):2106-15. doi: 10.1038/sj.jid.5700823. Epub 2007 Apr 12. J Invest Dermatol. 2007. PMID: 17429436

References

    1. Blanpain C, Lowry WE, Geoghegan A, Polak L, Fuchs E. Self-renewal, multipotency, and the existence of two cell populations within an epithelial stem cell niche. Cell. 2004;118:635–48. - PubMed
    1. Chen YP, Zhang Y, Jiang TX, Barlow A, Amand TR, Hu Y, et al. Conservation of early odontogenic signaling pathway in Aves. Proc Natl Acad Sci USA. 2000;97:10044–9. - PMC - PubMed
    1. Chuong CM, Wu P, Zhang FC, Xu X, Yu M, Widelitz RB, et al. Adaptation to the sky: Defining the feather with integument fossils from mesozoic China and experimental evidence from molecular laboratories. J Exp Zool. 2003;298B:42–56. - PMC - PubMed
    1. Chuong CM, Wu P, Plikus MV, Jiang TX, Widelitz RB. Engineering stem cells into organs: Topobiological transformations demonstrated by beak, feather and other ectodermal organ morphogenesis. Curr Topics Dev Biol. 2006;72:237–74. - PMC - PubMed
    1. Cotsarelis G. Epithelial stem cells: A folliculocentric view. J Invest Dermatol. 2006;126:1459–68. - PubMed

Publication types