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. 2007 Sep;43(14):2066-73.
doi: 10.1016/j.ejca.2007.07.005. Epub 2007 Aug 15.

Clinical and psychometric validation of a questionnaire module, the EORTC QLQ-OG25, to assess health-related quality of life in patients with cancer of the oesophagus, the oesophago-gastric junction and the stomach

Pernilla Lagergren  1 , Peter Fayers, Thierry Conroy, Hubert J Stein, Orhan Sezer, Richard Hardwick, Eva Hammerlid, Andrew Bottomley, Eric Van Cutsem, Jane M Blazeby; European Organisation for Research Treatment of Cancer Gastrointestinal and Quality of Life Groups
Affiliations

Clinical and psychometric validation of a questionnaire module, the EORTC QLQ-OG25, to assess health-related quality of life in patients with cancer of the oesophagus, the oesophago-gastric junction and the stomach

Pernilla Lagergren et al. Eur J Cancer. 2007 Sep.

Abstract

Aim: To combine and test the EORTC questionnaires for assessing quality of life (HRQL) for oesophageal (QLQ-OES18) and stomach cancer (QLQ-STO22), into a single questionnaire for tumours of the oesophagus, oesophago-gastric junction or stomach.

Methods: The QLQ-OES18, QLQ-STO22 and seven modified items were administered to 300 patients with oesophageal (n=148), junctional (n=66), or gastric cancer (n=86). Semi-structured interviews assessed item and scale preference and multi-trait scaling analyses confirmed the scale structure of the new module (QLQ-OG25). This was further tested for validity.

Results: The QLQ-OG25 has six scales, dysphagia, eating restrictions, reflux, odynophagia, pain and anxiety. Scales have good reliability (alpha range 0.67-0.87) and they distinguish between tumour sites and disease stage. Scales do not correlate highly with scores from the core questionnaire, thus indicating that the module was addressing separate HRQL aspects.

Conclusion: The QLQ-OG25 is recommended to supplement the EORTC QLQ-C30 when assessing HRQL in patients with oesophageal, junctional or gastric cancer.

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