Investigation of the lactate shuttle in skeletal muscle mitochondria
- PMID: 17702806
- PMCID: PMC2277175
- DOI: 10.1113/jphysiol.2007.142992
Investigation of the lactate shuttle in skeletal muscle mitochondria
Comment on
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Negligible direct lactate oxidation in subsarcolemmal and intermyofibrillar mitochondria obtained from red and white rat skeletal muscle.J Physiol. 2007 Aug 1;582(Pt 3):1317-35. doi: 10.1113/jphysiol.2007.135095. Epub 2007 Jun 7. J Physiol. 2007. PMID: 17556391 Free PMC article.
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References
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- Brooks GA. Glycolytic End Product and Oxidative Substrate During Sustained Exercise in Mammals – the ‘Lactate Shuttle. A. Berlin: Springer-Verlag; 1985. Respiration – Metabolism – Circulation.
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- Brooks GA. Lactate shuttles in nature. Biochem Soc Trans. 2002;30:258–264. - PubMed
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- Chatham JC, Des Rosiers C, Forder JR. Evidence of separate pathways for lactate uptake and release by the perfused rat heart. Am J Physiol Endocrinol Metab. 2001;281:E794–E802. - PubMed
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- Hashimoto T, Hussien R, Brooks GA. Colocalization of MCT1, CD147, and LDH in mitochondrial inner membrane of L6 muscle cells: evidence of a mitochondrial lactate oxidation complex. Am J Physiol Endocrinol Metab. 2006;290:E1237–E1244. - PubMed
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