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Review
. 2007 Sep;29(3):213-29.
doi: 10.1007/s00281-007-0079-y. Epub 2007 Aug 17.

NALP inflammasomes: a central role in innate immunity

Fabio Martinon  1 , Olivier Gaide, Virgine Pétrilli, Annick Mayor, Jürg Tschopp
Affiliations
Review

NALP inflammasomes: a central role in innate immunity

Fabio Martinon et al. Semin Immunopathol. 2007 Sep.

Abstract

Inflammasomes are cytoplasmic multiprotein complexes that mediate the maturation of the proinflammatory cytokines interleukin-1beta (IL-1beta), IL-18, and possibly IL-33 by controlling the activation of the inflammatory caspases-1 and -5. Assembly of inflammasomes depends on NOD-like receptor (NLR) family members such as NALPs, NAIP, and IPAF. Various microbial and endogenous stimuli activate different types of inflammasomes. This article focuses on the Pyrin domain containing NLRs, known as NALP proteins. Recent findings provide exciting insights into how these proteins might be activated and also provide evidence of the critical role of the NALP inflammasomes in innate immunity and inflammatory diseases.

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References

    1. Nature. 2006 Nov 16;444(7117):323-9 - PubMed
    1. Immunity. 2005 Dec;23(6):587-98 - PubMed
    1. J Biol Chem. 2007 Jan 26;282(4):2386-94 - PubMed
    1. Nat Genet. 2000 Nov;26(3):267-8 - PubMed
    1. J Biol Chem. 1993 Aug 25;268(24):18062-9 - PubMed

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