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Review
. 2007 Sep;57(3):467-83.
doi: 10.1016/j.jaad.2007.02.029.

Apocrine mixed tumor of the skin ("mixed tumor of the folliculosebaceous-apocrine complex"). Spectrum of differentiations and metaplastic changes in the epithelial, myoepithelial, and stromal components based on a histopathologic study of 244 cases

Dmitry V Kazakov  1 , Irena E Belousova, Michele Bisceglia, Eduardo Calonje, Michael Emberger, Wayne Grayson, Markus Hantschke, Werner Kempf, Heinz Kutzner, Michal Michal, Dominic V Spagnolo, Susanna Virolainen, Bernhard Zelger
Affiliations
Review

Apocrine mixed tumor of the skin ("mixed tumor of the folliculosebaceous-apocrine complex"). Spectrum of differentiations and metaplastic changes in the epithelial, myoepithelial, and stromal components based on a histopathologic study of 244 cases

Dmitry V Kazakov et al. J Am Acad Dermatol. 2007 Sep.

Abstract

Background: A systematic analysis of the entire spectrum of various forms of differentiation and metaplastic epiphenomena in cutaneous apocrine mixed tumor (AMT) has never been performed.

Objective: The purpose of our study was to study a large number of cutaneous mixed tumors so as to fully characterize the entire spectrum of differentiations and metaplastic changes that may occur in the epithelial, myoepithelial, and stromal components of AMT.

Methods: This article reports a light-microscopic study of 244 cases of cutaneous AMT, complemented by a literature review.

Results: All types of differentiation along the lines of the folliculosebaceous-apocrine unit can be seen in AMT. The spectrum of metaplastic changes in the epithelial components includes squamous metaplasia, mucinous metaplasia, oxyphilic metaplasia, clear cell change, columnar metaplasia, hobnail metaplasia, and cytoplasmic vacuolization. The following changes in the myoepithelial component were documented: clear cell change, hyaline cells, plasmacytoid cells, spindling, and collagenous spherulosis. Stromal alterations included chondroid metaplasia, osseous metaplasia, and adipose metaplasia.

Limitations: This study utilizes tissue specimens that mainly came as consultations; therefore some inherent selection bias exists.

Conclusions: AMT displays a wide range of differentiation and metaplastic changes in its epithelial, myoepithelial, and stromal components. These phenomena are not mutually exclusive. When unduly prominent, they may present diagnostic pitfalls. Our findings corroborate those of previous publications, stressing the remarkable diversity of differentiation and metaplasias that may be found in cutaneous AMT. We propose that the most appropriate name for these lesions is "mixed tumor of the folliculosebaceous-apocrine complex."

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