Review
doi: 10.1016/j.molcel.2007.08.003.
Polymerase switching in DNA replication
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- PMID: 17707225
- DOI: 10.1016/j.molcel.2007.08.003
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Review
Polymerase switching in DNA replication
Mol Cell.
.
Free article
Abstract
Our view of DNA replication has been of two coupled DNA polymerases anchored to the replication fork helicase in a "replisome" complex, synthesizing leading and lagging strands simultaneously. New evidence suggests that three DNA polymerases can be accommodated into the replisome and that polymerases and repair factors are dynamically recruited and engaged without dismantling of the replisome.
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