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Review
. 2008 Jun 1;147(1):153-9.
doi: 10.1016/j.jss.2007.06.015. Epub 2007 Jul 27.

Factors in the pathophysiology of the liver ischemia-reperfusion injury

Eduardo E Montalvo-Jave  1 , Tomas Escalante-Tattersfield, Jose A Ortega-Salgado, Enrique Piña, David A Geller
Affiliations
Review

Factors in the pathophysiology of the liver ischemia-reperfusion injury

Eduardo E Montalvo-Jave et al. J Surg Res. .

Abstract

Hepatic ischemia-reperfusion injury is commonplace in liver surgery, particularly in hepatic transplantation, hepatic resection, and trauma. The signaling events contributing to local hepatocellular damage are diverse and complex and involve the interaction between hepatocytes, sinusoidal endothelial cells, Kupffer cells, as well as infiltrating neutrophils, macrophages, and platelets. Signaling mediators include cytokines, reactive oxygen and nitrogen species, calcium, complement, and several transcription factors. The purpose of this review article was to summarize the factors that contribute to the pathophysiology of hepatic ischemia-reperfusion injury.

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Figures

Figure 1
Figure 1
Mechanisms involved in hepatic ischemia-reperfusion injury. Hepatocyte (HC), Sinusoidal Endothelial cell (SEC), Kupffer cell (KC), Neutrophil (PMN), Platelets (Plts), nitric oxide (NO), Endothelin (ET), Calcium (Ca2+), Adenosine triphosphate (ATP), Platelet activating factor (PAF), Reactive oxygen species (ROS)
See this image and copyright information in PMC

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