Comment on

• Spliceostatin A targets SF3b and inhibits both splicing and nuclear retention of pre-mRNA.

  Kaida D, Motoyoshi H, Tashiro E, Nojima T, Hagiwara M, Ishigami K, Watanabe H, Kitahara T, Yoshida T, Nakajima H, Tani T, Horinouchi S, Yoshida M. Kaida D, et al. Nat Chem Biol. 2007 Sep;3(9):576-83. doi: 10.1038/nchembio.2007.18. Epub 2007 Jul 22. Nat Chem Biol. 2007. PMID: 17643111
• Splicing factor SF3b as a target of the antitumor natural product pladienolide.

  Kotake Y, Sagane K, Owa T, Mimori-Kiyosue Y, Shimizu H, Uesugi M, Ishihama Y, Iwata M, Mizui Y. Kotake Y, et al. Nat Chem Biol. 2007 Sep;3(9):570-5. doi: 10.1038/nchembio.2007.16. Epub 2007 Jul 22. Nat Chem Biol. 2007. PMID: 17643112