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Comparative Study
. 2007 Sep;254(9):1170-3.
doi: 10.1007/s00415-006-0236-6. Epub 2006 Aug 20.

Depression in Parkinson's disease. Diffusion tensor imaging study

Hideaki Matsui  1 , Kazuto Nishinaka, Masaya Oda, Hidekazu Niikawa, Kenichi Komatsu, Tamotsu Kubori, Fukashi Udaka
Affiliations
Comparative Study

Depression in Parkinson's disease. Diffusion tensor imaging study

Hideaki Matsui et al. J Neurol. 2007 Sep.

Abstract

Objectives: The pathophysiology of depression and anxiety in Parkinson's disease remains obscure. We aimed to compare the fractional anisotropy (FA) values of Parkinson's disease (PD) patients with and without depression to investigate the nature of depression in PD.

Methods: Twenty-eight patients were divided into two groups: those with depression and those without. Diagnosis of depression was made using the DSM-IV criteria. Patients in the two groups were matched for Hoehn Yahr stage.

Results: There were significant reductions in FA values in the bilateral frontal ROIs possibly representing anterior cingulate bundles.

Conclusions: The anterior cingulate bundles play an important role in depression in PD, and some aspects of depression in PD have pathological processes in common with de novo depression.

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