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. 2007 Sep;45(6):513-8.
doi: 10.1080/13693780701390140.

Study of common functional genetic polymorphisms of FCGR2A, 3A and 3B genes and the risk for cryptococcosis in HIV-uninfected patients

Joseph Meletiadis  1 , Thomas J Walsh, Eun Hwa Choi, Peter G Pappas, David Ennis, Jeffrey Douglas, George A Pankey, Robert A Larsen, Richard J Hamill, Stephen Chanock
Affiliations

Study of common functional genetic polymorphisms of FCGR2A, 3A and 3B genes and the risk for cryptococcosis in HIV-uninfected patients

Joseph Meletiadis et al. Med Mycol. 2007 Sep.

Abstract

A pilot candidate gene association study was conducted to investigate the role of three common functional genetic polymorphisms of the low-affinity Fc gamma receptors, FCGR2A (131H/R), FCGR3A (158F/V) and FCGR3B (NA1/NA2) in Cryptococcus neoformans infections in individuals not infected with HIV. The FCGR2A 131RR and FCGR3A 158VV genotypes were over-represented [OR: 1.67 (1.05-2.63) and 2.04 (1.06-4.00), respectively] whereas the FCGR3B NA2NA2 was under-represented in patients with cryptococcosis (28% vs. 40% in controls). An analysis of haplotypes showed a significant difference in distribution between cases and controls overall and in Caucasians.

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