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Comparative Study
. 2007 Nov-Dec;42(6):509-12.
doi: 10.1093/alcalc/agm068. Epub 2007 Aug 21.

Association of the long allele of the 5-HTTLPR polymorphism with compulsive craving in alcohol dependence

Stefan Bleich  1 , Dominikus Bönsch, Johannes Rauh, Kristina Bayerlein, Roland Fiszer, Helge Frieling, Thomas Hillemacher
Affiliations
Comparative Study

Association of the long allele of the 5-HTTLPR polymorphism with compulsive craving in alcohol dependence

Stefan Bleich et al. Alcohol Alcohol. 2007 Nov-Dec.

Abstract

Aims: Various studies have reported a role of the serotonin transporter-linked polymorphic region (5-HTTLPR) in alcoholism.

Method: The present study investigated an association of this polymorphism with obsessive-compulsive alcohol craving in 124 male patients admitted for alcohol detoxification treatment.

Results: We found significantly higher compulsive craving in patients with the long allele of the 5-HTTLPR polymorphism [at admission: analysis of variance (ANOVA): F = 3.48, P = 0.034, general linear model: F = 3.92, P = 0.023; after 7 days: ANOVA: F = 3.12, P = 0.049].

Conclusions: Our results suggest that the long variant of the 5-HTTLPR polymorphism is associated with higher compulsive alcohol craving at the beginning of alcohol withdrawal.

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