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Multicenter Study
. 2007 Sep 15;45(6):736-40.
doi: 10.1086/520989. Epub 2007 Aug 10.

Prevalence and long-term effects of occult hepatitis B virus infection in HIV-infected women

Judith I Tsui  1 , Audrey L French, Eric C Seaberg, Michael Augenbraun, Marek Nowicki, Marion Peters, Phyllis C Tien
Affiliations
Multicenter Study

Prevalence and long-term effects of occult hepatitis B virus infection in HIV-infected women

Judith I Tsui et al. Clin Infect Dis. .

Abstract

Occult hepatitis B virus (HBV) infection is of concern in human immunodeficiency virus (HIV)-infected persons. We observed that 2% of 400 HIV-infected women with antibodies to hepatitis B core antigen alone had occult HBV infection (i.e., detectable HBV DNA in the absence of HBV surface antigen). CD4 cell counts of <200 cells/mm3 were more common among occult HBV-infected women than among those without occult HBV infection. Aminotransferase levels did not appear to be associated with being positive for HBV DNA.

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Conflict of interest statement

Potential conflicts of interest. All other authors: no conflicts.

Figures

Figure 1
Figure 1
Alanine aminotransferase (ALT; boxes) and CD4 cell levels (diamonds) and presence or absence of hepatitis B virus (HBV) DNA for patients 1, 2, and 6 in relation to antiretroviral therapy. ABC, abacavir; ddl, didanosine; d4t, stavudine; IDV, indinavir; LPV/r, lopinavir/ritonavir; NFV, nelfinavir; NVP, nevirapine; SQV, saquinavir; TDF, tenofovir; 3TC, lamivudine.
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