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Review
. 2007 Aug;4(8):1770-804.
doi: 10.1002/cbdv.200790152.

Human cannabinoid pharmacokinetics

Marilyn A Huestis  1
Affiliations
Review

Human cannabinoid pharmacokinetics

Marilyn A Huestis. Chem Biodivers. 2007 Aug.
No abstract available

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Figures

Fig. 1
Fig. 1
Mean (N=6) plasma concentrations of THC, 11-OH-THC, and THC-COOH during smoking of a single cannabis cigarette containing 3.55% of THC. Arrows (↓) indicate one inhalation or puff on the cannabis cigarette. Reprinted and adapted with permission by Springer-Verlag, ‘Handbook of Experimental Pharmacology’, 2005, p. 660, Fig. 1.
Fig. 2
Fig. 2
Time-dependent THC concentrations for six individuals (subjects B, C, and E–H) following smoking of a single cannabis cigarette containing 3.55% of THC. Reprinted and adapted with permission by Journal of Analytical Toxicology, p. 280 in [14], Fig. 1.
Fig. 3
Fig. 3
Plasma concentrations (N=1) over 24 h for THC, 11-OH-THC, and THC-COOH following administration of two doses (2.5 mg each) of synthetic THC (dronabinol) at 4.5 and 10.5 h. Reprinted and adapted with permission by Elsevier, p. 152 in [32], Fig. 2.
Fig. 4
Fig. 4
Predictive mathematical models for estimating the elapsed time of last cannabis use based on plasma THC and THC-COOH concentrations. Reprinted and adapted with permission by Journal of Analytical Toxicology, p. 285 in [140], Fig. 1.
Fig. 5
Fig. 5
Urine concentrations of THC-COOH and THC-COOH/creatinine for one subject following smoking of a single cannabis cigarette containing 3.55% of THC. Reprinted and adapted with permission by Journal of Analytical Toxicology, p. 450 in [148], Fig. 3.
Fig. 6
Fig. 6
Excretion patterns of THC in oral fluid and plasma, and urinary THC-COOH/creatinine levels in a human subject following smoking of a single cannabis cigarette containing 3.55% of THC. The THC-COOH/creatinine ratio is illustrated for all urine specimens collected through the last positive specimen. Analyses were performed by GC/MS at cutoff concentrations of 0.5 ng/ml for oral-fluid and plasma samples, and at 15 ng/ml for urine samples, resp. Reprinted and adapted with permission by Journal of Analytical Toxicology, p. 397 in [164], Fig. 2.
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References

    1. Turner CE, ElSohly MA, Boeren EG. J. Nat. Prod. 1980;43:169. - PubMed
    1. Claussen U, Korte F. Justus Liebigs Ann. Chem. 1968;713:162. - PubMed
    1. ElSohly HN, Boeren EG, Turner CE, ElSohly MA. In: The Cannabinoids: Chemical, Pharmacologic and Therapeutic Aspects. Agurell S, Dewey WL, Willette RE, editors. Academic Press; Orlando: 1984. p. 89.
    1. Mechoulam R. Science. 1970;168:1159. - PubMed
    1. Ohlsson A, Lindgren JE, Wahlen A, Agurell S, Hollister LE, Gillespie HK. Clin. Pharmacol. Ther. 1980;28:409. - PubMed

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