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. 2007 Sep;128(9):517-21.
doi: 10.1016/j.mad.2007.07.001. Epub 2007 Jul 7.

High innate production capacity of tumor necrosis factor-alpha and decline of handgrip strength in old age

Diana G Taekema  1 , Rudi G J Westendorp, Marijke Frölich, Jacobijn Gussekloo
Affiliations

High innate production capacity of tumor necrosis factor-alpha and decline of handgrip strength in old age

Diana G Taekema et al. Mech Ageing Dev. 2007 Sep.

Abstract

Increased signaling of the pro-inflammatory cytokine tumor necrosis factor-alpha (TNF-alpha) elicits apoptosis of skeletal muscle cells in various animal models. Within a population-based prospective follow up study of elderly people aged 85 years we show that a high innate production capacity of TNF-alpha precedes a steeper decline in muscle strength over time.

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