doi: 10.1021/ol7015498.
Epub 2007 Aug 23.
First enantioselective organocatalytic conjugate addition of aldehydes to vinyl phosphonates
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- PMID: 17715930
- DOI: 10.1021/ol7015498
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First enantioselective organocatalytic conjugate addition of aldehydes to vinyl phosphonates
Org Lett.
.
Abstract
Chiral amines catalyze the enantioselective conjugate addition of aldehydes to vinyl phosphonates in high yields and with enantioselectivities up to 97% ee. This novel process provides synthetically useful chiral gamma-geminal phosphonate aldehydes which can be easily converted in a few steps into chiral beta-substituted vinyl phosphonates with conservation of the optical purity.
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