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Review
. 2007 Nov;101(11-12):1657-66.
doi: 10.1016/j.jinorgbio.2007.07.014. Epub 2007 Jul 21.

Nickel and the carbon cycle

Stephen W Ragsdale  1
Affiliations
Review

Nickel and the carbon cycle

Stephen W Ragsdale. J Inorg Biochem. 2007 Nov.

Abstract

This article, dedicated to Edward Stiefel, reviews three nickel enzymes that play important roles in the carbon cycle: CO dehydrogenase, acetyl-CoA synthase, and methyl-coenzyme M reductase. After a short discussion of the carbon cycle, the structures of the active centers of the proteins and their proposed mechanisms are discussed. A brief description of future research areas is presented for each enzyme system. A short perspective on future research on nickel enzymes ends this contribution.

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Figures

Figure 1
Figure 1
The carbon cycle.
Figure 2
Figure 2
Metalloclusters at the active site of CODH, ACS, and MCR. (A). NiFe4S4 C-Cluster in CODH, (B) Ni2Fe4S4 A-Cluster in ACS, (C). Ni-tetrahydrocorphin (F430) in MCR, from Figure 1 of [95].
Figure 3
Figure 3
Proposed mechanism of CODH.
Figure 4
Figure 4
Metalloclusters in CODH based on the 1OAO structure from [23].
Figure 5
Figure 5
Proposed ACS mechanisms. (A) the paramagnetic mechanism and (B) the diamagnetic mechanism. The redox states of the metals has not been unambiguously determined in the catalytic mechanism
Figure 6
Figure 6
Proposed MCR mechanisms. Mechanism I involves a methyl-Ni intermediate and Mechanism II involves a methyl radical.
See this image and copyright information in PMC

References

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