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Review
. 2007 Dec;26(3-4):489-502.
doi: 10.1007/s10555-007-9094-7.

Tumour vascularization: sprouting angiogenesis and beyond

Femke Hillen  1 , Arjan W Griffioen
Affiliations
Review

Tumour vascularization: sprouting angiogenesis and beyond

Femke Hillen et al. Cancer Metastasis Rev. 2007 Dec.

Abstract

Tumour angiogenesis is a fast growing domain in tumour biology. Many growth factors and mechanisms have been unravelled. For almost 30 years, the sprouting of new vessels out of existing ones was considered as an exclusive way of tumour vascularisation. However, over the last years several additional mechanisms have been identified. With the discovery of the contribution of intussusceptive angiogenesis, recruitment of endothelial progenitor cells, vessel co-option, vasculogenic mimicry and lymphangiogenesis to tumour growth, anti-tumour targeting strategies will be more complex than initially thought. This review highlights these processes and intervention as a potential application in cancer therapy. It is concluded that future anti-vascular therapies might be most beneficial when based on multimodal anti-angiogenic, anti-vasculogenic mimicry and anti-lymphangiogenic strategies.

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Figures

Fig. 1
Fig. 1
Different mechanisms of tumour vascularisation. This diagram represents the six different types of vascularisation observed in solid tumours, including sprouting angiogenesis, intussusceptive angiogenesis, recruitment of endothelial progenitor cells, vessel co-option, vasculogenic mimicry and lymphangiogenesis. The main key players involved in these processes, if known, are indicated
See this image and copyright information in PMC

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