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. 2008;14(2):102-8.
doi: 10.1016/j.parkreldis.2007.06.011. Epub 2007 Aug 24.

Anxiety and depression: main determinants of health-related quality of life in Brazilian patients with Parkinson's disease

Francisco Javier Carod-Artal  1 , Sofia Ziomkowski, Hudson Mourão Mesquita, Pablo Martínez-Martin
Affiliations

Anxiety and depression: main determinants of health-related quality of life in Brazilian patients with Parkinson's disease

Francisco Javier Carod-Artal et al. Parkinsonism Relat Disord. 2008.

Abstract

Determinants of health-related quality of life (HRQoL) were assessed in 115 Brazilian patients (56.5% males; mean age 62.5 years) with Parkinson's disease (PD). Hoehn and Yahr (H&Y) staging, Scales for Outcomes in Parkinson's Disease-Motor Scale (SCOPA-MS), Cumulative Illness Rating Scale-Geriatrics, Hospital Anxiety and Depression Scale (HADS), Parkinson's Disease Questionnaire (PDQ-39), and SCOPA-Psychosocial Questionnaire (SCOPA-PS) were applied. Median H&Y was 3 and the SCOPA-MS score was 25.6+/-13.1. The proportion of patients who scored > or =11 points in the HADS-Depression and HADS-Anxiety subscales were 47% and 30.4%, respectively. In the multivariate model, HADS-Anxiety or HADS-Depression (p<0.0001), disability (SCOPA-MS II) (p=0.0001) and comorbidity (p=0.0005) were independently associated to PDQ-39 and SCOPA-PS. Mood disturbances were the main determinants of HRQoL.

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