Signal-to-noise optimization of HPLC-fluorometric systems and their application to the analysis of indoles
- PMID: 1772083
- DOI: 10.1007/978-1-4684-5952-4_5
Signal-to-noise optimization of HPLC-fluorometric systems and their application to the analysis of indoles
Abstract
The signal-to-noise optimization of high performance liquid chromatographic (HPLC) flow-cell fluorometric systems is described and the possibilities for further improving limits of detection for indoles is discussed. Application of HPLC-fluorometry to analyses in rat cerebrospinal fluid (CSF), human lumbar CSF, and human blood is presented. Finally, the intriguing clinical finding of hyperserotonemia in autism is discussed.
Similar articles
-
High-performance liquid chromatographic determination of indoleamines, dopamine, and norepinephrine in rat brain with fluorometric detection.Anal Biochem. 1983 Feb 1;128(2):275-80. doi: 10.1016/0003-2697(83)90375-5. Anal Biochem. 1983. PMID: 6189418
-
High-performance liquid chromatographic measurement of tryptophan in blood, tissues, urine, and foodstuffs with electrochemical and fluorometric detections.Agric Biol Chem. 1991 Jun;55(6):1475-81. Agric Biol Chem. 1991. PMID: 1368702
-
Determination of kynurenic acid in rat cerebrospinal fluid by HPLC with fluorescence detection.Biomed Chromatogr. 2016 Jan;30(1):62-7. doi: 10.1002/bmc.3492. Epub 2015 May 12. Biomed Chromatogr. 2016. PMID: 25963282
-
Chromatographic methods in the study of autism.Biomed Chromatogr. 2013 Oct;27(10):1273-9. doi: 10.1002/bmc.2911. Epub 2013 Apr 22. Biomed Chromatogr. 2013. PMID: 23605782 Review.
-
High-performance liquid chromatographic determination of histamine in biological samples: the cerebrospinal fluid challenge--a review.Anal Chim Acta. 2013 Apr 24;774:1-10. doi: 10.1016/j.aca.2012.12.041. Epub 2013 Jan 3. Anal Chim Acta. 2013. PMID: 23567111 Review.
Cited by
-
Single-Shot Detection of Neurotransmitters in Whole-Blood Samples by Means of the Heat-Transfer Method in Combination with Synthetic Receptors.Sensors (Basel). 2017 Nov 23;17(12):2701. doi: 10.3390/s17122701. Sensors (Basel). 2017. PMID: 29168733 Free PMC article.