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. 2007 Dec;102(1):53-6.
doi: 10.1007/s00436-007-0721-6. Epub 2007 Aug 26.

Molecular cloning and characterization of WD40-repeat protein from Clonorchis sinensis

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Molecular cloning and characterization of WD40-repeat protein from Clonorchis sinensis

Pyo Yun Cho et al. Parasitol Res. 2007 Dec.

Abstract

WD40-repeat proteins have four to eight repeating units flanked by Gly-His (GH) and Trp-Asp (WD) at both termini and folds into a beta-propeller. A polypeptide deduced from a Clonorchis sinensis cDNA clone analyzed to have seven WD40-repeats and predicted to form a beta-propeller (CsWD1). The CsWD1 protein was expressed stage-specifically in the metacercariae and localized in the tegumental syncytium. The CsWD1 protein is suggested to serve as a platform for interacting partner proteins in the tegumental syncytium of C. sinensis metacercariae.

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