This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features!

Skip to main page content

Add to Collections

Your saved search

Name of saved search:

Search terms:

Test search terms

Would you like email updates of new search results?

Yes
No

Email: (change)

Frequency:

Which day?

Which day?

Report format:

Send at most:

Send even when there aren't any new results

Optional text in email:

Your RSS Feed

. 2007 Sep 19;129(37):11300-1.

doi: 10.1021/ja072157y. Epub 2007 Aug 28.

A single-point mutation converts the highly amyloidogenic human islet amyloid polypeptide into a potent fibrillization inhibitor

Andisheh Abedini¹, Fanling Meng, Daniel P Raleigh

Affiliations

PMID: 17722920
DOI: 10.1021/ja072157y

A single-point mutation converts the highly amyloidogenic human islet amyloid polypeptide into a potent fibrillization inhibitor

Andisheh Abedini et al. J Am Chem Soc. 2007.

. 2007 Sep 19;129(37):11300-1.

doi: 10.1021/ja072157y. Epub 2007 Aug 28.

Authors

Andisheh Abedini¹, Fanling Meng, Daniel P Raleigh

Affiliation

¹ Department of Chemistry, State University of New York at Stony Brook, Stony Brook, New York 11794-3400, USA.

PMID: 17722920
DOI: 10.1021/ja072157y

No abstract available

PubMed Disclaimer

Similar articles

Inhibition of beta-amyloid fibrillization by directed evolution of a beta-sheet presenting miniature protein.
Smith TJ, Stains CI, Meyer SC, Ghosh I. Smith TJ, et al. J Am Chem Soc. 2006 Nov 15;128(45):14456-7. doi: 10.1021/ja065557e. J Am Chem Soc. 2006. PMID: 17090018
Porcine islet amyloid polypeptide fragments are refractory to amyloid formation.
Zhang X, Cheng B, Gong H, Li C, Chen H, Zheng L, Huang K. Zhang X, et al. FEBS Lett. 2011 Jan 3;585(1):71-7. doi: 10.1016/j.febslet.2010.11.050. Epub 2010 Dec 3. FEBS Lett. 2011. PMID: 21130765
New strategy for the generation of specific D-peptide amyloid inhibitors.
Esteras-Chopo A, Pastor MT, Serrano L, López de la Paz M. Esteras-Chopo A, et al. J Mol Biol. 2008 Apr 11;377(5):1372-81. doi: 10.1016/j.jmb.2008.01.028. Epub 2008 Jan 16. J Mol Biol. 2008. PMID: 18328503
Backbone-modified amylin derivatives: implications for amyloid inhibitor design and as template for self-assembling bionanomaterials.
Elgersma RC, Posthuma G, Rijkers DT, Liskamp RM. Elgersma RC, et al. J Pept Sci. 2007 Nov;13(11):709-16. doi: 10.1002/psc.831. J Pept Sci. 2007. PMID: 17890652 Review.
Historical background.
Young A. Young A. Adv Pharmacol. 2005;52:1-18. doi: 10.1016/S1054-3589(05)52001-5. Adv Pharmacol. 2005. PMID: 16492538 Review. No abstract available.

See all similar articles

Cited by

Contribution of the 12-17 hydrophobic region of islet amyloid polypeptide in self-assembly and cytotoxicity.
Fortier M, Côté-Cyr M, Nguyen V, Babych M, Nguyen PT, Gaudreault R, Bourgault S. Fortier M, et al. Front Mol Biosci. 2022 Oct 3;9:1017336. doi: 10.3389/fmolb.2022.1017336. eCollection 2022. Front Mol Biosci. 2022. PMID: 36262476 Free PMC article.
Conformationally restricted short peptides inhibit human islet amyloid polypeptide (hIAPP) fibrillization.
Mishra A, Misra A, Vaishnavi TS, Thota C, Gupta M, Ramakumar S, Chauhan VS. Mishra A, et al. Chem Commun (Camb). 2013 Apr 4;49(26):2688-90. doi: 10.1039/c3cc38982k. Chem Commun (Camb). 2013. PMID: 23435449 Free PMC article.
Role and Cytotoxicity of Amylin and Protection of Pancreatic Islet β-Cells from Amylin Cytotoxicity.
Kiriyama Y, Nochi H. Kiriyama Y, et al. Cells. 2018 Aug 6;7(8):95. doi: 10.3390/cells7080095. Cells. 2018. PMID: 30082607 Free PMC article. Review.
Recent insights in islet amyloid polypeptide-induced membrane disruption and its role in beta-cell death in type 2 diabetes mellitus.
Khemtémourian L, Killian JA, Höppener JW, Engel MF. Khemtémourian L, et al. Exp Diabetes Res. 2008;2008:421287. doi: 10.1155/2008/421287. Exp Diabetes Res. 2008. PMID: 18483616 Free PMC article. Review.
Graphene oxide inhibits hIAPP amyloid fibrillation and toxicity in insulin-producing NIT-1 cells.
Nedumpully-Govindan P, Gurzov EN, Chen P, Pilkington EH, Stanley WJ, Litwak SA, Davis TP, Ke PC, Ding F. Nedumpully-Govindan P, et al. Phys Chem Chem Phys. 2016 Jan 7;18(1):94-100. doi: 10.1039/c5cp05924k. Epub 2015 Dec 2. Phys Chem Chem Phys. 2016. PMID: 26625841 Free PMC article.

See all "Cited by" articles

Publication types

Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions

Substances

Actions
Actions
Actions

LinkOut - more resources

Full Text Sources
- American Chemical Society
Other Literature Sources
- The Lens - Patent Citations Database