Outcome of idiopathic thrombocytopenic purpura in pregnancy in King Chulalongkorn Memorial Hospital

Abstract

Objective: To study the maternal and fetal outcome of idiopathic thrombocytopenic purpura (ITP) in pregnancy.

Material and method: The medical records of women who were diagnosed to be idiopathic thrombocytopenic purpura during and before pregnancy from January 1995 to December 2004 were reviewed.

Results: There were 33pregnancies from 29 ITP women as four women had two pregnancies each and one was twins. Nine cases (27.3%) were active ITP, five cases (15.2%) were relapsing ITP and eight cases (24.2%) were inactive ITP. Eleven cases (33.3%) had severe thrombocytopenia during delivery and five neonates (23.8%) had severe thrombocytopenia. There was no statistical correlation between maternal and neonatal platelet concentration (r = -0.0601). None of the mothers and fetuses had serious hemorrhagic complication such as intracranial hemorrhage.

Conclusion: There were low hemorrhagic risks in both mothers and infants because of the constant monitoring of multidisciplinary groups of experienced physicians, including obstetricians, hematologists, anesthesiologists and neonatologist.