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. 2007 Sep 17;97(6):730-4.
doi: 10.1038/sj.bjc.6603944. Epub 2007 Aug 28.

MUC-1 gene is associated with prostate cancer death: a 20-year follow-up of a population-based study in Sweden

O Andrén  1 , K Fall, S-O Andersson, M A Rubin, T A Bismar, M Karlsson, J-E Johansson, L A Mucci
Affiliations

MUC-1 gene is associated with prostate cancer death: a 20-year follow-up of a population-based study in Sweden

O Andrén et al. Br J Cancer. .

Abstract

Anti-adhesion mucins have proven to play an important part in the biology of several types of cancer. Therefore, we test the hypothesis that altered expression of MUC-1 is associated with prostate cancer progression. We retrieved archival tumour tissue from a population-based cohort of 195 men with localised prostate cancer (T1a-b, Nx, M0) that has been followed for up to 20 years with watchful waiting. Semi-automated, quantitative immunohistochemistry was undertaken to evaluate MUC-1 expression. We modelled prostate cancer-specific death as a function of MUC-1 levels accounting for age, Gleason grade and tumour extent, and calculated age-adjusted and multivariate adjusted hazard ratios (HR). Men that had tumours with an MUC-intensity lower or higher than normal tissue had a higher risk of dying in prostate cancer, independent of tumour extent and Gleason score (HR 5.1 and 4.5, respectively). Adjustment for Gleason grade and tumour stage did not alter the results. Men with a Gleason score > or =7 and MUC-1 deviating from the normal had a 17 (RR=17.1 95% confidence interval=2.3-128) times higher risk to die in prostate cancer compared with men with Gleason score <7 and normal MUC-1 intensity. In summary, our data show that MUC-1 is an independent prognostic marker for prostate cancer death.

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Figures

Figure 1
Figure 1
Tissue micro array analysis of MUC-1 immunohistochemistry: selected images of TMA cores representing normal, high and low MUC-1 intensity (A, B). Normal MUC-1 intensity (C, D). High (C) and Low (D) MUC-1 intensity.
Figure 2
Figure 2
Survival curves of 195 patients according to high-, low- and normal MUC-1 intensity.
Figure 3
Figure 3
Survival curves of 195 patients according to combination of Gleason score and MUC-1 intensity.
See this image and copyright information in PMC

References

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