PET probe-guided surgery
- PMID: 17726667
- DOI: 10.1002/jso.20862
PET probe-guided surgery
Abstract
Intraoperative localization of PET-positive recurrent/metastatic lesions can be facilitated using a hand-held PET probe. PET probe is a high-energy gamma probe designed to process the 511 keV photons of PET tracers. Intraoperative gamma probe performance is a function of radiopharmaceutical uptake, clearance kinetics, and probe engineering, all determining the target to background ratio (TBR) and detection threshold. A minimum TBR of 1.5:1 is needed in the operative field for the operating surgeon to be comfortable the differences between tumor tissue and normal adjacent tissue are real. Due to high-energy photon fluxes, achieving a satisfactory TBR intraoperatively is challenging and requires development of a clinically feasible PET-probe guided surgery protocol.
Similar articles
-
PET probe-guided surgery: applications and clinical protocol.World J Surg Oncol. 2007 Jun 7;5:65. doi: 10.1186/1477-7819-5-65. World J Surg Oncol. 2007. PMID: 17555587 Free PMC article.
-
Radioguided surgery using an intraoperative PET probe for tumor localization and verification of complete resection in differentiated thyroid cancer: a pilot study.Surgery. 2011 Mar;149(3):416-24. doi: 10.1016/j.surg.2010.08.004. Epub 2010 Oct 20. Surgery. 2011. PMID: 20965536
-
PET-Probe: Evaluation of Technical Performance and Clinical Utility of a Handheld High-Energy Gamma Probe in Oncologic Surgery.Ann Surg Oncol. 2016 Dec;23(Suppl 5):9020-9027. doi: 10.1245/ASO.2006.05.047. Epub 2006 Jul 24. Ann Surg Oncol. 2016. PMID: 16865592
-
Probe-guided localization of cancer deposits using [18F]fluorodeoxyglucose.Q J Nucl Med Mol Imaging. 2008 Mar;52(1):37-49. Q J Nucl Med Mol Imaging. 2008. PMID: 17657203 Review.
-
Positron emission tomography for radiation treatment planning.Strahlenther Onkol. 2005 Aug;181(8):483-99. doi: 10.1007/s00066-005-1422-7. Strahlenther Onkol. 2005. PMID: 16044216 Review.
Cited by
-
A comprehensive overview of radioguided surgery using gamma detection probe technology.World J Surg Oncol. 2009 Jan 27;7:11. doi: 10.1186/1477-7819-7-11. World J Surg Oncol. 2009. PMID: 19173715 Free PMC article. Review.
-
Sentinel Lymph Node Detection in Early-Stage Oral Squamous Cell Carcinoma Using Magnetic Resonance Lymphography: A Pilot Study.J Clin Med. 2024 Nov 22;13(23):7052. doi: 10.3390/jcm13237052. J Clin Med. 2024. PMID: 39685510 Free PMC article.
-
New Developments in Imaging for Sentinel Lymph Node Biopsy in Early-Stage Oral Cavity Squamous Cell Carcinoma.Cancers (Basel). 2020 Oct 20;12(10):3055. doi: 10.3390/cancers12103055. Cancers (Basel). 2020. PMID: 33092093 Free PMC article. Review.
-
Intra-operative use of PET probe for localization of FDG avid lesions.Cancer Imaging. 2009 Sep 29;9(1):59-62. doi: 10.1102/1470-7330.2009.0009. Cancer Imaging. 2009. PMID: 19933018 Free PMC article.
-
Comparison of two threshold detection criteria methodologies for determination of probe positivity for intraoperative in situ identification of presumed abnormal 18F-FDG-avid tissue sites during radioguided oncologic surgery.BMC Cancer. 2014 Sep 13;14:667. doi: 10.1186/1471-2407-14-667. BMC Cancer. 2014. PMID: 25218021 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
