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. 2007 Sep;8(9):638-46.
doi: 10.1631/jzus.2007.B0638.

Identification of a high frequency of chromosomal rearrangements in the centromeric regions of prostate cancer patients

V Balachandar  1 , B Lakshman Kumar, K Sasikala, P Manikantan, R Sangeetha, S Mohana Devi
Affiliations

Identification of a high frequency of chromosomal rearrangements in the centromeric regions of prostate cancer patients

V Balachandar et al. J Zhejiang Univ Sci B. 2007 Sep.

Abstract

The aim of the present investigation was to study the major chromosomal aberrations (CA) like deletion, translocation, inversion and mosaic in prostate cancer patients of Tamilnadu, Southern India. Totally 45 blood samples were collected from various hospitals in Tamilnadu, Southern India. Equal numbers of normal healthy subjects were chosen after signing a consent form. Volunteers provided blood samples (5 ml) to establish leukocyte cultures. Cytogenetic studies were performed by using Giemsa-banding technique and finally the results were ensured by spectral karyotyping (SKY) technique. In the present investigation, major CA like deletion, translocation, inversion and mosaic were identified in experimental subjects. Results showed frequent CA in chromosomes 1, 3, 5, 6, 7, 9, 13, 16, 18 and X. In comparison with experimental subjects, the control subjects exhibited very low levels of major CA (P<0.05). In the present study, the high frequency of centromeric rearrangements indicates a potential role for mitotic irregularities associated with the centromere in prostate cancer tumorigenesis. Identification of chromosome alterations may be helpful in understanding the molecular basis of the disease in better manner.

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Figures

Fig. 1
Fig. 1
Correlation for the total number of chromosomal aberrations (CA) in 100 cells scored per subject prostate cancer. The CA recorded is calculated as per 100 subjects in each group
Fig. 2
Fig. 2
Correlation for the total number of chromosomal aberrations (CA) in 100 cells scored per control. The CA recorded is calculated as per 100 controls in each group
See this image and copyright information in PMC

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