Beta-amino acid-containing hybrid peptides--new opportunities in peptidomimetics
- PMID: 17728852
- DOI: 10.1039/b708507a
Beta-amino acid-containing hybrid peptides--new opportunities in peptidomimetics
Abstract
Hybrid peptides consisting of alpha-amino acids with judiciously placed beta-amino acids show great promise as peptidomimetics in an increasing range of therapeutic applications. This reflects a combination of increased stability, high specificity and relative ease of synthesis.
Similar articles
-
The proteolytic stability of 'designed' beta-peptides containing alpha-peptide-bond mimics and of mixed alpha,beta-peptides: application to the construction of MHC-binding peptides.Chem Biodivers. 2005 May;2(5):591-632. doi: 10.1002/cbdv.200590039. Chem Biodivers. 2005. PMID: 17192006
-
Foldamers containing γ-amino acid residues or their analogues: structural features and applications.Amino Acids. 2011 Aug;41(3):687-707. doi: 10.1007/s00726-011-0893-3. Epub 2011 Apr 1. Amino Acids. 2011. PMID: 21455734 Review.
-
Beta-peptidic peptidomimetics.Acc Chem Res. 2008 Oct;41(10):1366-75. doi: 10.1021/ar700263g. Epub 2008 Jun 26. Acc Chem Res. 2008. PMID: 18578513
-
Solid-phase synthesis of "mixed" peptidomimetics using Fmoc-protected aza-beta3-amino acids and alpha-amino acids.J Org Chem. 2005 Dec 23;70(26):10701-8. doi: 10.1021/jo051585o. J Org Chem. 2005. PMID: 16355988
-
Conformational properties of hybrid peptides containing alpha- and omega-amino acids.J Pept Res. 2004 Mar;63(3):279-89. doi: 10.1111/j.1399-3011.2004.00143.x. J Pept Res. 2004. PMID: 15049840 Review.
Cited by
-
5-Amino-3-methyl-Isoxazole-4-carboxylic Acid as a Novel Unnatural Amino Acid in the Solid Phase Synthesis of α/β-Mixed Peptides.Molecules. 2022 Aug 31;27(17):5612. doi: 10.3390/molecules27175612. Molecules. 2022. PMID: 36080386 Free PMC article.
-
"Cut and Paste" Processes in the Search of Bioactive Products: One-Pot, Metal-free O-Radical Scission-Oxidation-Addition of C, N or P-Nucleophiles.Front Chem. 2022 May 18;10:884124. doi: 10.3389/fchem.2022.884124. eCollection 2022. Front Chem. 2022. PMID: 35665068 Free PMC article. Review.
-
Evaluation of β-Amino Acid Replacements in Protein Loops: Effects on Conformational Stability and Structure.Chembiochem. 2018 Mar 16;19(6):604-612. doi: 10.1002/cbic.201700580. Epub 2018 Feb 13. Chembiochem. 2018. PMID: 29272560 Free PMC article.
-
Efficient synthesis of β-aminonitriles from arynes and imines in acetonitrile.RSC Adv. 2024 Oct 23;14(46):33747-33750. doi: 10.1039/d4ra04499a. eCollection 2024 Oct 23. RSC Adv. 2024. PMID: 39450062 Free PMC article.
-
Quaternary β2,2-amino acid derivatives by asymmetric addition of isoxazolidin-5-ones to para-quinone methides.Chem Commun (Camb). 2020 Jan 14;56(4):579-582. doi: 10.1039/c9cc09239k. Epub 2019 Dec 12. Chem Commun (Camb). 2020. PMID: 31830176 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources