Review
doi: 10.1080/08916930701464897.
Protein tyrosine phosphatase PTPN22 in human autoimmunity
Affiliations
- PMID: 17729039
- DOI: 10.1080/08916930701464897
Item in Clipboard
Review
Protein tyrosine phosphatase PTPN22 in human autoimmunity
Autoimmunity.
2007 Sep.
Free article
Abstract
The discovery that a single-nucleotide polymorphism (SNP) in lymphoid tyrosine phosphatase (LYP), encoded by the PTPN22 gene, is associated with type 1 diabetes (T1D) has now been verified by numerous studies and has been expanded to rheumatoid arthritis, juvenile rheumatoid arthritis (JRA), systemic lupus erythematosus, Graves' disease, generalized vitiligo and other human autoimmune diseases. In this paper, we discuss the association of PTPN22 with autoimmunity, the biochemistry of the PTPN22-encoded phosphatase, and the molecular mechanism(s) by which the disease-predisposing allele contributes to the development of human disease.
Similar articles
-
Association analysis of the 1858C>T polymorphism in the PTPN22 gene in juvenile idiopathic arthritis and other autoimmune diseases.Genes Immun. 2005 May;6(3):271-3. doi: 10.1038/sj.gene.6364178. Genes Immun. 2005. PMID: 15759012
-
Association of the lymphoid tyrosine phosphatase R620W variant with rheumatoid arthritis, but not Crohn's disease, in Canadian populations.Arthritis Rheum. 2005 Jul;52(7):1993-8. doi: 10.1002/art.21123. Arthritis Rheum. 2005. PMID: 15986374
-
Role of PTPN22 in type 1 diabetes and other autoimmune diseases.Semin Immunol. 2006 Aug;18(4):207-13. doi: 10.1016/j.smim.2006.03.008. Epub 2006 May 11. Semin Immunol. 2006. PMID: 16697661 Review.
-
PTPN22 gene polymorphism in Behçet's disease.Tissue Antigens. 2007 Nov;70(5):432-4. doi: 10.1111/j.1399-0039.2007.00928.x. Epub 2007 Sep 16. Tissue Antigens. 2007. PMID: 17868256
-
Lymphoid-specific tyrosine phosphatase (Lyp): a potential drug target for treatment of autoimmune diseases.Curr Drug Targets. 2014 Mar;15(3):335-46. doi: 10.2174/13894501113146660236. Curr Drug Targets. 2014. PMID: 24188455 Review.
Cited by
-
The Contribution of PTPN22 to Rheumatic Disease.Arthritis Rheumatol. 2019 Apr;71(4):486-495. doi: 10.1002/art.40790. Epub 2019 Mar 2. Arthritis Rheumatol. 2019. PMID: 30507064 Free PMC article. Review.
-
Target identification reveals protein arginine methyltransferase 1 is a potential target of phenyl vinyl sulfone and its derivatives.Biosci Rep. 2018 Apr 20;38(2):BSR20171717. doi: 10.1042/BSR20171717. Print 2018 Apr 26. Biosci Rep. 2018. PMID: 29540535 Free PMC article.
-
The immunogenetics of multiple sclerosis.Immunogenetics. 2008 Jun;60(6):275-86. doi: 10.1007/s00251-008-0295-1. Epub 2008 May 7. Immunogenetics. 2008. PMID: 18461312 Review.
-
Lack of the Association of the PTPN22 C1858T Gene Polymorphism With Susceptibility to Familial Mediterranean Fever.Arch Rheumatol. 2016 Apr 13;31(2):107-111. doi: 10.5606/ArchRheumatol.2016.5788. eCollection 2016 Jun. Arch Rheumatol. 2016. PMID: 29900952 Free PMC article.
-
PTPN22 and islet-specific autoimmunity: What have the mouse models taught us?World J Diabetes. 2017 Jul 15;8(7):330-336. doi: 10.4239/wjd.v8.i7.330. World J Diabetes. 2017. PMID: 28751955 Free PMC article. Review.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Medical
Molecular Biology Databases
