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Review
. 2007 Sep 21;13(35):4737-45.
doi: 10.3748/wjg.v13.i35.4737.

Liver-gut axis in the regulation of iron homeostasis

Deepak Darshan  1 , Gregory-J Anderson
Affiliations
Review

Liver-gut axis in the regulation of iron homeostasis

Deepak Darshan et al. World J Gastroenterol. .

Abstract

The human body requires about 1-2 mg of iron per day for its normal functioning, and dietary iron is the only source for this essential metal. Since humans do not possess a mechanism for the active excretion of iron, the amount of iron in the body is determined by the amount absorbed across the proximal small intestine and, consequently, intestinal iron absorption is a highly regulated process. In recent years, the liver has emerged as a central regulator of both iron absorption and iron release from other tissues. It achieves this by secreting a peptide hormone called hepcidin that acts on the small intestinal epithelium and other cells to limit iron delivery to the plasma. Hepcidin itself is regulated in response to various systemic stimuli including variations in body iron stores, the rate of erythropoiesis, inflammation and hypoxia, the same stimuli that have been known for many years to modulate iron absorption. This review will summarize recent findings on the role played by the liver and hepcidin in the regulation of body iron absorption.

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Figures

Figure 1
Figure 1
Sequence alignment of hepcidin from various species.
Figure 2
Figure 2
Signalling pathways for HAMP regulation.
Figure 3
Figure 3
A model for the liver-dependent regulation of iron homeostasis.
See this image and copyright information in PMC

References

    1. McKie AT, Barrow D, Latunde-Dada GO, Rolfs A, Sager G, Mudaly E, Mudaly M, Richardson C, Barlow D, Bomford A, et al. An iron-regulated ferric reductase associated with the absorption of dietary iron. Science. 2001;291:1755–1759. - PubMed
    1. Gunshin H, Mackenzie B, Berger UV, Gunshin Y, Romero MF, Boron WF, Nussberger S, Gollan JL, Hediger MA. Cloning and characterization of a mammalian proton-coupled metal-ion transporter. Nature. 1997;388:482–488. - PubMed
    1. Shayeghi M, Latunde-Dada GO, Oakhill JS, Laftah AH, Takeuchi K, Halliday N, Khan Y, Warley A, McCann FE, Hider RC, et al. Identification of an intestinal heme transporter. Cell. 2005;122:789–801. - PubMed
    1. McKie AT, Marciani P, Rolfs A, Brennan K, Wehr K, Barrow D, Miret S, Bomford A, Peters TJ, Farzaneh F, et al. A novel duodenal iron-regulated transporter, IREG1, implicated in the basolateral transfer of iron to the circulation. Mol Cell. 2000;5:299–309. - PubMed
    1. Anderson GJ, Vulpe CD. Regulation of intestinal iron transport. In: Templeton D, ed , editors. Molecular and Cellular Iron Transport. New York: Marcel Dekker; 2001.