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. 1944 Sep 1;100(2592):198-200.
doi: 10.1126/science.100.2592.198.

INHIBITION OF beta HEMOLYTIC STREPTOCOCCI FIBRINOLYSIN BY TRYPSIN INHIBITOR (ANTIPROTEASE)

I A Mirsky

INHIBITION OF beta HEMOLYTIC STREPTOCOCCI FIBRINOLYSIN BY TRYPSIN INHIBITOR (ANTIPROTEASE)

I A Mirsky. Science. .

Abstract

Crystalline "trypsin-inhibitor" of pancreatic origin and the antitrypsin of soybean origin completely inhibit the fibrinolytic activity of cultures of beta hemolytic streptococci, of filtrates of such cultures and of concentrates of such filtrates. It is suggested that the streptococcal fibrinolysin is a protease and that it may be related to trypsin. The author wishes to acknowledge gratefully the cooperation of Lieutenant Colonel Robert L. King, Lieutenant Colonel E. D. Embree and Captain Edward Freis.

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