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. 1991 Nov;29(11):2666-7.
doi: 10.1128/jcm.29.11.2666-2667.1991.

Nontoxigenic strains of Clostridium difficile lack the genes for both toxin A and toxin B

A C Fluit  1 , M J Wolfhagen, G P Verdonk, M Jansze, R Torensma, J Verhoef
Affiliations

Nontoxigenic strains of Clostridium difficile lack the genes for both toxin A and toxin B

A C Fluit et al. J Clin Microbiol. 1991 Nov.

Abstract

A total of 39 toxigenic and 20 nontoxigenic strains of Clostridium difficile were tested for the presence of either toxin A or toxin B by the polymerase chain reaction (PCR). All toxigenic strains produced cytotoxin as assayed by using highly sensitive fetal lung fibroblasts and were positive for toxin A as well as toxin B in the PCR assay. All nontoxigenic strains failed to produce toxin and were negative in the PCR assay. This study shows that nontoxigenic strains of Clostridium difficile lack the toxin A as well as the toxin B gene.

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References

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