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. 1991 Oct;33(4):305-10.
doi: 10.1007/BF02102861.

Strand symmetry of mutation rates in the beta-globin region

M Bulmer  1
Affiliations

Strand symmetry of mutation rates in the beta-globin region

M Bulmer. J Mol Evol. 1991 Oct.

Abstract

It has been suggested that there may be inequalities in the types of substitution on the two DNA strands (in particular, in the frequencies of transversions from R to Y and from Y to R) due to a higher error rate on the lagging than the leading strand during replication. Reexamination of 11 kb of the beta-globin region sequenced in six primates fails to confirm this suggestion. Examination of the 73-kb beta-globin region sequenced in humans shows that the frequency of pyrimidines in different parts of this region is more variable than expected in a random sequence, but the pattern is more consistent with nonrandomness generated by DNA turnover mechanisms than with strand asymmetry due to a higher error rate on the lagging strand.

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