doi: 10.1126/science.246.4928.371.
Toward protein tertiary structure recognition by means of associative memory hamiltonians
- PMID: 17747919
- DOI: 10.1126/science.246.4928.371
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Toward protein tertiary structure recognition by means of associative memory hamiltonians
Science.
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Abstract
The statistical mechanics of associative memories and spin glasses suggests ways to design Hamiltonians for protein folding. An associative memory Hamiltonian based on hydrophobicity patterns is shown to have a large capacity for recall and to be capable of recognizing tertiary structure for moderately variant sequences.
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