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. 1991 Nov;49(1):119-31.
doi: 10.1016/0166-6851(91)90135-s.

Primary structure and localization of a conserved immunogenic Plasmodium falciparum glutamate rich protein (GLURP) expressed in both the preerythrocytic and erythrocytic stages of the vertebrate life cycle

M B Borre  1 , M Dziegiel, B Høgh, E Petersen, K Rieneck, E Riley, J F Meis, M Aikawa, K Nakamura, M Harada, et al.
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Primary structure and localization of a conserved immunogenic Plasmodium falciparum glutamate rich protein (GLURP) expressed in both the preerythrocytic and erythrocytic stages of the vertebrate life cycle

M B Borre et al. Mol Biochem Parasitol. 1991 Nov.

Abstract

A gene coding for a 220-kDa glutamate rich protein (GLURP), an exoantigen of Plasmodium falciparum, was isolated and its nucleotide sequence was determined. The deduced amino acid sequence contains 2 repeat regions. The sequence of one of these was shown to be conserved among geographically dispersed isolates, and a fusion protein containing that sequence was able to stimulate B- and T-cells. Antibodies against GLURP stained erythrocytic stages of the parasite as well as the hepatic stage as detected by electron microscopy.

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