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. 1991 Nov;49(1):99-110.
doi: 10.1016/0166-6851(91)90133-q.

Primary structure of a Plasmodium falciparum rhoptry antigen

H J Brown  1 , R L Coppel
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Primary structure of a Plasmodium falciparum rhoptry antigen

H J Brown et al. Mol Biochem Parasitol. 1991 Nov.

Abstract

The high-molecular-weight rhoptry complex of Plasmodium falciparum consists of 3 non-covalently associated polypeptides of 150, 135 and 105 kDa. We present the complete nucleotide sequence of the 105-kDa (RhopH3) component of this complex derived from analysis of genomic and cDNA clones. The genomic structure is unusually complex for P. falciparum, consisting of 7 exons including 2 mini-exons of 19 and 21 amino acids. The sequence lacks tandem repeats and is conserved among several parasite isolates. B cell epitopes that induce antibody responses during natural infection were mapped to five different regions of the polypeptide.

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