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. 1991 Nov;419(5):540-2.
doi: 10.1007/BF00370803.

Trans effects of cellular K and Cl on ouabain-resistant Rb(K) influx in low K sheep red blood cells: further evidence for asymmetry of K-Cl cotransport [corrected]

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Trans effects of cellular K and Cl on ouabain-resistant Rb(K) influx in low K sheep red blood cells: further evidence for asymmetry of K-Cl cotransport [corrected]

E Delpire et al. Pflugers Arch. 1991 Nov.

Erratum in

  • Pflugers Arch 1992 Jan;420(1):124

Abstract

The electroneutral K-Cl cotransport in low K+ (LK) sheep red blood cells is kinetically asymmetric and thermodynamically outward poised (Delpire and Lauf, 1991a). We have shown previously by trans-inhibition kinetics that Cl- binds prior to K+ to the outside configuration of the carrier. In the present study, we confirm that K+ and Cl- bind randomly to the cytoplasmic aspect of the transporter because K+ in the absence of Cl-, and Cl- in the absence of K+, trans-inhibit ouabain-resistant Rb+(K+) influx in these cells. In contrast to the trans-inhibition pattern observed outside, neither K+ nor Cl- trans-inhibit K+(Rb+) influx in the presence of the cotransported ion, further supporting the asymmetry of the K-Cl cotransporter.

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