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. 2007 Aug 30:2:34.
doi: 10.1186/1746-1596-2-34.

Synchronously diagnosed lymph nodal collision tumor of malignant melanoma and chronic lymphocytic leukemia/small lymphocytic lymphoma: case report

Dina El Demellawy  1 , Catherine Ross, Monalisa Sur, Salem Alowami
Affiliations

Synchronously diagnosed lymph nodal collision tumor of malignant melanoma and chronic lymphocytic leukemia/small lymphocytic lymphoma: case report

Dina El Demellawy et al. Diagn Pathol. .

Abstract

Synchronous composite tumors have been described but are uncommon. Moreover, simultaneous occurrence of synchronous tumors in the same tissue or organ is even less common. We report a case of chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma and malignant melanoma (MM) occurring synchronously in the same lymph node. Several cases of an association between cutaneous malignancies and lymphoproliferative disorders have been reported. Some of which included CLL and MM, occurring in the same patient often CLL after MM. The risk of having CLL after MM has been reported to be increased. Various genetic and environmental etiologies have been postulated, but have as yet not been proven. To our knowledge this is the first time that synchronous occurrence of these two malignant processes in the same tissue is described. In this case it is important that the melanoma was recognized in the excised lymph node, as this finding had much more critical treatment and long term survival consequences.

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Figures

Figure 1
Figure 1
Lymph node involved with chronic lymphocytic leukemia showing architectural effacement, (HE 40×).
Figure 2
Figure 2
Restricted expression of CD5 within the lymphocytes in chronic lymphocytic leukemia in contrast to malignant melanoma cells, (CD5 200×).
Figure 3
Figure 3
Restricted expression of Bcl-2 within the lymphocytes in chronic lymphocytic leukemia in contrast to malignant melanoma cells, (Bcl-2 200×).
Figure 4
Figure 4
Restricted expression of CD23 within the lymphocytes in chronic lymphocytic leukemia in contrast to malignant melanoma cells, (CD23 200×).
Figure 5
Figure 5
Simultaneous lymph node involvement by large epithelioid melanoma cells and small monotonous lymphocytes of chronic lymphocytic leukemia, (HE 200×).
Figure 6
Figure 6
Expression of Melanoma cocktail within the cytoplasmic membranes of the malignant melanoma cells, (Melanoma cocktail 400×).
Figure 7
Figure 7
Expression of S100 within the nuclei and cytoplasm of the malignant melanoma cells, (Melanoma cocktail 400×).
See this image and copyright information in PMC

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