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Multicenter Study
. 2007 Dec;18(12):1976-80.
doi: 10.1093/annonc/mdm365. Epub 2007 Aug 30.

Adjuvant treatment of early breast cancer: do the St Gallen recommendations influence clinical practice? Results from the NORA study

M E Cazzaniga  1 , G Mustacchi, P Pronzato, A De Matteis, F Di Costanzo, I Floriani; NORA Study Group
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Free article
Multicenter Study

Adjuvant treatment of early breast cancer: do the St Gallen recommendations influence clinical practice? Results from the NORA study

M E Cazzaniga et al. Ann Oncol. 2007 Dec.
Free article

Abstract

Background: The NORA study is a prospective longitudinal cohort study aiming at investigating treatment in patients with early breast cancer. Here, we present the impact of the St Gallen recommendations on clinical practice.

Patients and methods: We compared adjuvant strategies in patients enrolled in 2000-2002 to those in 2003-2004 to verify the impact of the 2003 St Gallen recommendations.

Results: The use of aromatase inhibitors (AIs) doubled: 65/629 patients (10.3%) vs 100/458 patients (21.8) (P < 0.0001). Following chemotherapy, AIs were administered in 8.5% of the retrospective cohort and in 15.1% of the prospective one (P < 0.0001). The use of taxanes plus hormones dropped (P = 0.0026), but not when used as single agents. A marked increase was observed in the use of anthracycline-based chemotherapy (46.3% vs 65.2%), mainly three-drug regimens (33.3% vs 46.6%).

Conclusion: Our results suggest that the St Gallen recommendations have had a major impact on clinical practice.

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