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Randomized Controlled Trial
. 2007 Sep;9(9):947-54.
doi: 10.1080/14622200701540820.

Efficacy of bupropion alone and in combination with nicotine gum

Megan E Piper  1 , E Belle Federman, Danielle E McCarthy, Daniel M Bolt, Stevens S Smith, Michael C Fiore, Timothy B Baker
Affiliations
Randomized Controlled Trial

Efficacy of bupropion alone and in combination with nicotine gum

Megan E Piper et al. Nicotine Tob Res. 2007 Sep.

Abstract

In this double-blind, placebo-controlled smoking cessation treatment study, 608 participants were randomly assigned to receive active bupropion and active 4-mg gum (AA, n = 228), active bupropion and placebo gum (AP, n = 224), or placebo bupropion and placebo gum (PP, n = 156). Relative to the PP group, the AA and AP groups were each significantly more likely to be abstinent at 1 week, end of treatment, and 6 months but not at 12 months postquit. After the first week postquit there were no differences in abstinence rates between the AA and AP groups. We found no significant individual difference variables that moderated outcome beyond 1 week postquit.

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Figures

Figure 1
Figure 1
CONSORT figure of participant flow through the study.
Figure 2
Figure 2
Survival curves for the three treatment conditions
See this image and copyright information in PMC

References

    1. Ascher JA, Cole JO, Colin JN, Feighner JP, Ferris RM, Fibiger HC, Golden RN, Martin P, Potter WZ, Richelson E, et al. Bupropion: A review of its mechanisms of antidepressant activity. Journal of Clinical Psychiatry. 1995;56:395–401. - PubMed
    1. Baker TB, Morse E, Sherman JE. The motivation to use drugs: A psychobiological analysis of urges. In: Rivers C, editor. Nebraska symposium on motivation. Lincoln: University of Nebraska Press; 1987. pp. 257–323. - PubMed
    1. Baker TB, Piper ME, McCarthy DE, Majeskie MR, Fiore MC. Addiction motivation reformulated: An affective processing model of negative reinforcement. Psychological Review. 2004;111:33–51. - PubMed
    1. Bjornson W, Rand C, Connett JE, Lindgren P, Nides M, Pope F, Buist AS, Hoppe-Ryan C, O’Hara P. Gender differences in smoking cessation after three years in the Lung Health Study. American Journal of Public Health. 1995;85:223–230. - PMC - PubMed
    1. Bohadana A, Nilsson F, Rasmussen T, Martinet Y. Gender differences in quit rates following smoking cessation with combination nicotine therapy: Influence of baseline smoking behavior. Nicotine & Tobacco Research. 2003;5:111–116. - PubMed

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