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. 2007 Oct 1;196(7):1006-9.
doi: 10.1086/521309. Epub 2007 Aug 23.

Risk of hepatocellular carcinoma and secondary structure of hepatitis C virus (HCV) NS3 protein amino-terminus, in patients infected with HCV subtype 1b

Yuko Nishise  1 , Takafumi Saito, Kazuhiko Sugahara, Jun-Itsu Ito, Koji Saito, Hitoshi Togashi, Motoko Nagano-Fujii, Hak Hotta, Sumio Kawata
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Risk of hepatocellular carcinoma and secondary structure of hepatitis C virus (HCV) NS3 protein amino-terminus, in patients infected with HCV subtype 1b

Yuko Nishise et al. J Infect Dis. .

Abstract

We conducted a retrospective study of 65 patients with chronic hepatitis C, to determine whether the secondary structure of the amino-terminal 120 residues of the hepatitis C virus (HCV) NS3 protein is associated with an increased risk of development of hepatocellular carcinoma (HCC). The cumulative incidence of HCC was highest among patients infected with group B HCV-1b, wherein the risk of HCC significantly increased compared with that among patients infected with group A (hazard ratio, 4.95 [95% CI, 1.43-17.11]) after adjustment for age and histological stage. This HCV-1b grouping may be a useful marker for detecting the risk of development of HCC.

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