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. 2008 Mar;53(3):844-9.
doi: 10.1007/s10620-007-9934-x. Epub 2007 Sep 1.

Immunohistochemical expression of components of the Akt-mTORC1 pathway is associated with hepatocellular carcinoma in patients with chronic liver disease

Scott J Cotler  1 , Nissim Hay, Hui Xie, Mei Ling Chen, Pei Zhang Xu, Thomas J Layden, Grace Guzman
Affiliations

Immunohistochemical expression of components of the Akt-mTORC1 pathway is associated with hepatocellular carcinoma in patients with chronic liver disease

Scott J Cotler et al. Dig Dis Sci. 2008 Mar.

Abstract

Activation of the Akt-mTORC1 signaling pathway was evaluated in premalignant and hepatocellular carcinoma (HCC) lesions by assessing the expression of pS6, an Akt effector, and PTEN, an Akt suppressor.

Methods: Immunohistochemical staining for pS6 and PTEN was performed on liver tissue from 52 patients with cirrhosis, with and without HCC. Two pathologists independently evaluated pS6 staining on a semiquantitative scale and categorized PTEN staining as present or absent.

Results: In the HCC group, pS6 staining was greatest in HCC, followed by dysplasia, and benign cirrhotic tissue (P < 0.001). pS6 staining was greater in cirrhotic tissue from patients with HCC compared to cirrhosis in patients without HCC (P = 0.03). PTEN staining in tumor was absent in 8/33 (24%) cases. Loss of PTEN expression was more common in patients with higher tumor stage, compared to those with stage 1 tumors (P = 0.04).

Conclusion: Immunohistochemical evidence of activation of the Akt-mTORC1 pathway is associated with HCC.

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References

    1. Nat Rev Mol Cell Biol. 2006 Feb;7(2):85-96 - PubMed
    1. Cancer. 2005 Jan 15;103(2):307-12 - PubMed
    1. Liver Transpl. 2004 Oct;10(10):1301-11 - PubMed
    1. J Clin Invest. 2004 Jun;113(12 ):1774-83 - PubMed
    1. Carcinogenesis. 2002 Jan;23(1):201-5 - PubMed