Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2007 Sep;37(7):721-4.
doi: 10.1007/s11055-007-0073-9.

The differential contribution of dopamine D(1) and D (2) receptors to mu-opioidergic immunomodulation

M A Cheido  1 , G V Idova
Affiliations

The differential contribution of dopamine D(1) and D (2) receptors to mu-opioidergic immunomodulation

M A Cheido et al. Neurosci Behav Physiol. 2007 Sep.

Abstract

Activation of mu-opioid receptors (mu-OR) by the highly selective agonist DAGO (100 microg/kg) significantly increased the immune response in CBA mice. This effect of the mu agonist was prevented by prior blockade of dopamine D(2) receptors with haloperidol (2 mg/kg). In contrast, the selective D(1) receptor antagonist SCH 23390 (1 mg/kg) had no effect on the nature of the immune reaction in response to antigen (sheep erythrocytes, 5 x 10(8) cells). However, blockade of both types of dopamine receptor led to the same effect--immunosuppression. These data lead to the suggestion that D(1) and D(2) receptors make different contributions to modulating immunogenesis on activation of mu-OR.

PubMed Disclaimer

References

    1. Int J Neurosci. 1988 Jun;40(3-4):271-88 - PubMed
    1. Eur J Pharmacol. 1981 Apr 9;70(4):531-40 - PubMed
    1. Pharmacol Biochem Behav. 1999 Jun;63(2):245-52 - PubMed
    1. NIDA Res Monogr. 1990;105:82-8 - PubMed
    1. Nature. 1965 Sep 4;207(5001):1106-7 - PubMed

Publication types

MeSH terms

LinkOut - more resources