Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2007;8(8):222.
doi: 10.1186/gb-2007-8-8-222.

Antagonizing Methuselah to extend life span

Nazif Alic  1 , Linda Partridge
Affiliations
Review

Antagonizing Methuselah to extend life span

Nazif Alic et al. Genome Biol. 2007.

Abstract

A recent report describes the identification through the use of in vitro selection of a peptide that antagonizes Methuselah signaling in Drosophila in vitro and extends fly life span in vivo.

PubMed Disclaimer

Figures

Figure 1
Figure 1
The location of RWR peptide binding to the Mth ectodomain. The Mth ectodomain structure [13] was visualized with PyMOL (PyMOL Molecular Graphics System). The tryptophan (W) residue previously thought to be positioned at the ligand-binding site is indicated in green, and the region near the carboxyl terminus to which the RWR peptide was located by Ja et al. [2] is indicated by an orange circle.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Lin YJ, Seroude L, Benzer S. Extended life-span and stress resistance in the Drosophila mutant methuselah. Science. 1998;282:943–946. doi: 10.1126/science.282.5390.943. - DOI - PubMed
    1. Ja WW, West AP, Jr, Delker SL, Bjorkman PJ, Benzer S, Roberts RW. Extension of Drosophila melanogaster life span with a GPCR peptide inhibitor. Nat Chem Biol. 2007;3:415–419. doi: 10.1038/nchembio.2007.2. - DOI - PMC - PubMed
    1. Mockett RJ, Sohal RS. Temperature-dependent trade-offs between longevity and fertility in the Drosophila mutant, methuselah. Exp Gerontol. 2006;41:566–573. doi: 10.1016/j.exger.2006.03.015. - DOI - PubMed
    1. Baldal EA, Baktawar W, Brakefield PM, Zwaan BJ. Methuselah life history in a variety of conditions, implications for the use of mutants in longevity research. Exp Gerontol. 2006;41:1126–1135. doi: 10.1016/j.exger.2006.08.014. - DOI - PubMed
    1. Song W, Ranjan R, Dawson-Scully K, Bronk P, Marin L, Seroude L, Lin YJ, Nie Z, Atwood HL, Benzer S, et al. Presynaptic regulation of neurotransmission in Drosophila by the G protein-coupled receptor methuselah. Neuron. 2002;36:105–119. doi: 10.1016/S0896-6273(02)00932-7. - DOI - PubMed

Publication types

MeSH terms

LinkOut - more resources