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Comment
. 2007 Nov;18(9):329-30.
doi: 10.1016/j.tem.2007.08.004. Epub 2007 Aug 30.

Hormones and postpartum cardiomyopathy

Carmen Clapp  1 , Stéphanie Thebault, Gonzalo Martínez de la Escalera
Affiliations
Comment

Hormones and postpartum cardiomyopathy

Carmen Clapp et al. Trends Endocrinol Metab. 2007 Nov.

Abstract

Prolactin, a hormone fundamental for lactation, was recently shown to mediate postpartum cardiomyopathy, a life-threatening disease in late-term and lactating mothers. The detrimental effect of prolactin results from myocardial upregulation of cathepsin-D, which in turn cleaves prolactin to a 16 kDa fragment (vasoinhibin) with anti-angiogenic and pro-apoptotic properties that impair developing cardiac vasculature.

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  • A cathepsin D-cleaved 16 kDa form of prolactin mediates postpartum cardiomyopathy.
    Hilfiker-Kleiner D, Kaminski K, Podewski E, Bonda T, Schaefer A, Sliwa K, Forster O, Quint A, Landmesser U, Doerries C, Luchtefeld M, Poli V, Schneider MD, Balligand JL, Desjardins F, Ansari A, Struman I, Nguyen NQ, Zschemisch NH, Klein G, Heusch G, Schulz R, Hilfiker A, Drexler H. Hilfiker-Kleiner D, et al. Cell. 2007 Feb 9;128(3):589-600. doi: 10.1016/j.cell.2006.12.036. Cell. 2007. PMID: 17289576 Clinical Trial.

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