Comment
doi: 10.1016/j.devcel.2007.08.006.
Coping with stress: ATF6alpha takes the stage
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- PMID: 17765676
- DOI: 10.1016/j.devcel.2007.08.006
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Comment
Coping with stress: ATF6alpha takes the stage
Dev Cell.
2007 Sep.
Free article
Abstract
In this issue of Developmental Cell, two groups, Yamamoto et al. and Wu et al., describe the generation of mice with targeted deletion of the ATF6alpha gene. While ATF6alpha is nonessential for embryonic and postnatal development, deletion has a profound effect on the transcriptional program elicited by endoplasmic reticulum stress, revealing a broader than anticipated role for ATF6 in this signaling network.
Comment on
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ATF6alpha optimizes long-term endoplasmic reticulum function to protect cells from chronic stress.Dev Cell. 2007 Sep;13(3):351-64. doi: 10.1016/j.devcel.2007.07.005. Dev Cell. 2007. PMID: 17765679
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Transcriptional induction of mammalian ER quality control proteins is mediated by single or combined action of ATF6alpha and XBP1.Dev Cell. 2007 Sep;13(3):365-76. doi: 10.1016/j.devcel.2007.07.018. Dev Cell. 2007. PMID: 17765680
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