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. 2007 Oct;39(10):1200-1.
doi: 10.1038/ng2131. Epub 2007 Sep 2.

Variation in complement factor 3 is associated with risk of age-related macular degeneration

Julian B Maller  1 , Jesen A Fagerness, Robyn C Reynolds, Benjamin M Neale, Mark J Daly, Johanna M Seddon
Affiliations

Variation in complement factor 3 is associated with risk of age-related macular degeneration

Julian B Maller et al. Nat Genet. 2007 Oct.

Abstract

The association of variants in complement factors H and B with age-related macular degeneration has led to more intense genetic and functional analysis of the complement pathway. We identify a nonsynonymous coding change in complement factor 3 that is strongly associated with risk of age-related macular degeneration in a large case-control sample.

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