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. 2007 Oct;39(10):1197-9.
doi: 10.1038/ng2108. Epub 2007 Sep 2.

A QTL influencing F cell production maps to a gene encoding a zinc-finger protein on chromosome 2p15

Stephan Menzel  1 , Chad Garner, Ivo Gut, Fumihiko Matsuda, Masao Yamaguchi, Simon Heath, Mario Foglio, Diana Zelenika, Anne Boland, Helen Rooks, Steve Best, Tim D Spector, Martin Farrall, Mark Lathrop, Swee Lay Thein
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A QTL influencing F cell production maps to a gene encoding a zinc-finger protein on chromosome 2p15

Stephan Menzel et al. Nat Genet. 2007 Oct.

Abstract

F cells measure the presence of fetal hemoglobin, a heritable quantitative trait in adults that accounts for substantial phenotypic diversity of sickle cell disease and beta thalassemia. We applied a genome-wide association mapping strategy to individuals with contrasting extreme trait values and mapped a new F cell quantitative trait locus to BCL11A, which encodes a zinc-finger protein, on chromosome 2p15. The 2p15 BCL11A quantitative trait locus accounts for 15.1% of the trait variance.

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