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. 2007 Sep 3:3:14.
doi: 10.1186/1745-0179-3-14.

Antipsychotics dosage and antiparkinsonian prescriptions

Eric Acquaviva  1 , Isabelle Gasquet, Bruno Falissard
Affiliations

Antipsychotics dosage and antiparkinsonian prescriptions

Eric Acquaviva et al. Clin Pract Epidemiol Ment Health. .

Abstract

Background: To study the link between the dosage of several antipsychotics and the prescription of antiparkinsonians in an observational study.

Methods: In the context of a national naturalistic prospective observational study, a database containing all the prescriptions from 100 French psychiatrists during the year 2002 was analysed. The inclusion criteria were a diagnosis of schizophrenia or schizoaffective disorder and age over 18. The mean dosage of antipsychotics with and without antiparkinsonians was compared. Since there were multiple prescriptions for a given subject, generalised mixed linear models were also used to study the link between antiparkinsonian prescription and antipsychotic dosage.

Results: antiparkinsonians were prescribed to 32,9% of the patients. Two groups of antipsychotics were observed relating to differences in dosage when an antiparkinsonian was co prescribed or not : a first group, where the mean dosage was higher with antiparkinsonians (risperidone, amisulpride and haloperidol) and a second group (clozapine, olanzapine), in which antiparkinsonian co prescription was not related to the dosage of antipsychotics.

Conclusion: As a conclusion, it can be said that it is important to consider the dosage and the type of antipsychotic in the treatment of patients suffering of schizophrenia, because neurological side effects are frequent and can impair quality of life. Moreover the prescription of antiparkinsonians can lead to different side effects such anticholinergic effects.

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Figures

Figure 1
Figure 1
Antipsychotics dosage and antiparkinsonian prescriptions. 100 mg equivalent dosage in chlorpromazine = 10 mg of olanzapine. = 50 mg of clozapine. = 5 mg of haloperidol. = 3 mg of risperidone.
See this image and copyright information in PMC

References

    1. Pierre JM. Extrapyramidal symptoms with atypical antipsychotics: incidence, prevention and management. Drug Saf. 2005;28:191–208. doi: 10.2165/00002018-200528030-00002. - DOI - PubMed
    1. Sachdev PS. Neuroleptic-induced movement disorders: an overview. Psychiatr Clin North Am. 2005;28:255–73. doi: 10.1016/j.psc.2004.10.004. - DOI - PubMed
    1. Lader M. Some adverse effects of antipsychotics: prevention and treatment. J Clin Psychiatry. 1999;60(Suppl 12):18–2. - PubMed
    1. ANAES. Stratégies thérapteutiques à long terme dans les psychoses schizophréniques. Conférence de consensus: Paris; 1994.
    1. Liebermann JA, Stroup TS, Mc Evoy JP, Swartz MS, Rosenheck RA, Perkins DO, Keefe RS, Davis CE, Lebowitz BD, Hsia JK. Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) Investigators: Effectiveness of antipsychotic drugs in patients with chronic schizophrenia. NEJM. 2005;353:1209–23. doi: 10.1056/NEJMoa051688. - DOI - PubMed