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Review
. 2007;9 Suppl 2(Suppl 2):S10.
doi: 10.1186/ar2194.

Clinical trials and basic research: defining mechanisms and improving treatment in connective tissue disease

Lewis J Rubin  1 , Carol M Black, Christopher P Denton, James R Seibold
Affiliations
Review

Clinical trials and basic research: defining mechanisms and improving treatment in connective tissue disease

Lewis J Rubin et al. Arthritis Res Ther. 2007.

Abstract

Despite advances in elucidating the pathogenic factors responsible for its development, systemic sclerosis remains complex and poorly understood, and treatment options are limited. Multidisciplinary collaborative efforts are needed to better characterize clinical and prognostic parameters and to design and implement large-scale clinical trials in well defined populations with therapies that target potential disease modulators.

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