Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2007 Sep;92(9):1270-2.
doi: 10.3324/haematol.11010.

Down-regulation of WT1/+17AA gene expression using RNAi and modulating leukemia cell chemotherapy resistance

Huiling Shen, Wenlin Xu, Zhaoyang Wu, Huarong Tang, Yanyan Xie, Ximing Zhong
Free article

Down-regulation of WT1/+17AA gene expression using RNAi and modulating leukemia cell chemotherapy resistance

Huiling Shen et al. Haematologica. 2007 Sep.
Free article

Abstract

We have shown that inhibition of WT1/+17AA protein expression following transfection with a vector-based small interfering RNA expression construct in K562 cell lines, leads to a decrease in MDR1 and P-glycoprotein levels, accumulation of Rh123, and enhancement of the doxorubicin cytotoxicity. Our findings suggest that WT1/+17AA exerts its oncogenic function by modulating multidrug resistance in leukemia cells.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

Publication types

MeSH terms

Substances

LinkOut - more resources