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. 1983 Jul 8;221(4606):165-7.
doi: 10.1126/science.221.4606.165.

agr-Amanitin Tolerance in Mycophagous Drosophila

J Jaenike, D A Grimaldi, A E Sluder, A L Greenleaf

agr-Amanitin Tolerance in Mycophagous Drosophila

J Jaenike et al. Science. .

Abstract

Six species of Drosophila were tested for tolerance to the mushroom toxin alpha-amanitin, a potent inhibitor of RNA polymerase II. Three nonmycophagous species-D. melanogaster, D. immigrans, and D. pseudoobscura-showed very low survival and long development times in the presence of amanitin. Three mycophagous species-D. putrida, D. recens, and D. tripunctata-showed little or no sensitivity. Analysis in vitro indicated that this tolerance is not based on alteration of the molecular structure of RNA polymerase II.

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